Article
Low-level GATA2 overexpression promotes myeloid progenitor self-renewal and blocks lymphoid differentiation in mice.
Experimental hematology - 1 Jul 2015
Nandakumar Satish K, Johnson Kyle, Throm Stacy L, Pestina Tamara I, Neale Geoffrey, Persons Derek A
Abstract excerpt
The transcription factor GATA2 is highly expressed in hematopoietic stem cells and is downregulated during lineage maturation. Gain of function mutations, loss of function mutations, and overexpression of GATA2 have been reported in acute myeloid leukemia. In previous studies, we and others showed that GATA2 overexpression at high levels, similar to that seen in hematopoietic stem cells, blocked differentiation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.