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Article

Tumor suppressor function of Gata2 in acute promyelocytic leukemia.

Blood - 30 Sept 2021

Katerndahl Casey D S, Rogers Olivia R S, Day Ryan B, Cai Michelle A, Rooney Timothy P, Helton Nichole M, Hoock Mieke, Ramakrishnan Sai Mukund, Nonavinkere Srivatsan Sridhar, Wartman Lukas D, Miller Christopher A, Ley Timothy J

Abstract excerpt

Most patients with acute promyelocytic leukemia (APL) can be cured with combined all-trans retinoic acid (ATRA) and arsenic trioxide therapy, which induces the destruction of PML-RARA, the initiating fusion protein for this disease. However, the underlying mechanisms by which PML-RARA initiates and maintains APL cells are still not clear. Therefore, we identified genes that are dysregulated by PML-RARA in mouse...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Leukemia, Promyelocytic, Acute

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Identifiers

PMID: 34125173
DOI: 10.1182/blood.2021011758
PMCID: PMC8570055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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