Article
The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development.
Cell - 15 Jul 1994
Warren A J, Colledge W H, Carlton M B, Evans M J, Smith A J, Rabbitts T H
Abstract excerpt
The LIM domain protein rbtn2 is associated with T cell acute leukemias. We demonstrate that rbtn2 is a nuclear protein expressed in the erythroid lineage in vivo, and using homologous recombination, we show that it is essential for erythroid development in mice. The homozygous rbtn2 null mutation leads to failure of yolk sac erythropoiesis and embryonic lethality around E10.5. Moreover, in vitro differentiation...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- Antibody Specificity
- Base Sequence
- Cell Line
- Cell Nucleus
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Erythroid Precursor Cells
- Erythropoiesis