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Article

Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015

Hu Wenjun, Begum Nasim A, Mondal Samiran, Stanlie Andre, Honjo Tasuku

Abstract excerpt

Activation-induced cytidine deaminase (AID) is essential for antibody class switch recombination (CSR) and somatic hypermutation (SHM). AID originally was postulated to function as an RNA-editing enzyme, based on its strong homology with apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 1 (APOBEC1), the enzyme that edits apolipoprotein B-100 mRNA in the presence of the APOBEC cofactor APOBEC1...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Heterogeneous-Nuclear Ribonucleoproteins

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Share to Somatic Hypermutation, Immunoglobulin

Source

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Identifiers

PMID: 25902538
DOI: 10.1073/pnas.1506167112
PMCID: PMC4426456

Genes

APOBEC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase.PMID 25902538Read ↗

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