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Article

Point mutations in alpha-subunit of human cardiac Na+ channels alter Na+ current kinetics.

Biochemical and biophysical research communications - 16 Feb 2001

Xiao Y F, Ke Q, Wang S Y, Yang Y, Wang G K, Morgan J P, Leaf A

Abstract excerpt

Dietary polyunsaturated fatty acids (PUFAs) prevent ischemia-induced fatal cardiac arrhythmias in animals and probably in humans. This action results from inhibition of ion currents for Na+, Ca2+, and possibly other ions. To extend understanding of this protection we are seeking a possible binding site for the PUFAs on the alpha-subunit of the human cardiac Na+ channel, hH1alpha, transiently expressed in HEK293t...

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Identifiers

PMID: 11178958
DOI: 10.1006/bbrc.2001.4309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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