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Article

Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1.

Biochemistry - 2 Nov 2021

Liu Yilin, Grinkova Yelena, Gregory Michael C, Denisov Ilia G, Kincaid James R, Sligar Stephen G

Abstract excerpt

Steroid metabolism in humans originates from cholesterol and involves several enzyme reactions including dehydrogenation, hydroxylation, and carbon-carbon bond cleavage that occur at regio- and stereo-specific points in the four-membered ring structure. Cytochrome P450s occur at critical junctions that control the production of the male sex hormones (androgens), the female hormones (estrogens) as well as the...

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Identifiers

PMID: 34662099
DOI: 10.1021/acs.biochem.1c00282
PMCID: PMC8822902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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