Article
IRF6 Is a Marker of Severity in Nonsyndromic Cleft Lip/Palate.
Journal of dental research - 1 Sept 2015
Kerameddin S, Namipashaki A, Ebrahimi S, Ansari-Pour N
Abstract excerpt
Nonsyndromic cleft lip with or without palate (CL/P) is thought to be caused by the interplay of genetic and environmental factors, and this has thus hindered the process of identifying genetic causative factors. Numerous studies in the past decade have implicated IRF6 in CL/P, but this has not often been replicated in other populations. In specific, the only etiologic single-nucleotide polymorphism (SNP)...
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