Article
Breakthroughs in the genetics of orofacial clefting.
Trends in molecular medicine - 1 Dec 2011
Mangold Elisabeth, Ludwig Kerstin U, Nöthen Markus M
Abstract excerpt
Nonsyndromic orofacial clefts have a multifactorial etiology, involving both genetic and environmental factors. Although linkage and candidate gene studies have attempted to elucidate the underlying genetic architecture, only the interferon regulatory factor 6 (IRF6) gene has been identified as causative. The recent introduction of high-throughput genotyping technologies has enabled researchers to perform...
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