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Article

Breakthroughs in the genetics of orofacial clefting.

Trends in molecular medicine - 1 Dec 2011

Mangold Elisabeth, Ludwig Kerstin U, Nöthen Markus M

Abstract excerpt

Nonsyndromic orofacial clefts have a multifactorial etiology, involving both genetic and environmental factors. Although linkage and candidate gene studies have attempted to elucidate the underlying genetic architecture, only the interferon regulatory factor 6 (IRF6) gene has been identified as causative. The recent introduction of high-throughput genotyping technologies has enabled researchers to perform...

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Identifiers

PMID: 21885341
DOI: 10.1016/j.molmed.2011.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Breakthroughs in the genetics of orofacial clefting.PMID 21885341Read ↗

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Identifying Genetic Sources of Phenotypic Heterogeneity in Orofacial Clefts by Targeted Sequencing.Semantic proximity Read ↗

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