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Article

IRF6 is a risk factor for nonsyndromic cleft lip in the Brazilian population.

American journal of medical genetics. Part A - 1 Sept 2012

Brito Luciano A, Bassi Camila F S, Masotti Cibele, Malcher Carolina, Rocha Kátia M, Schlesinger David, Bueno Daniela F, Cruz Lucas A, Barbara Ligia K, Bertola Débora R, Meyer Diogo, Franco Diogo, Alonso Nivaldo, Passos-Bueno Maria Rita

Abstract excerpt

Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a complex disorder with a worldwide incidence estimated at 1:700. Among the putative susceptibility loci, the IRF6 gene and a region at 8q24.21 have been corroborated in different populations. To test the role of IRF6 in NSCL/P predisposition in the Brazilian population, we conducted a structured association study with the SNPs rs642961 and rs590223,...

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PMID: 22887868
DOI: 10.1002/ajmg.a.35526

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IRF6 is a risk factor for nonsyndromic cleft lip in the Brazilian population.PMID 22887868Read ↗

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