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Article

Implications of telomere‐independent activities of telomerase reverse transcriptase in human cancer

25 Mar 2013

Abstract excerpt

Telomerase plays a pivotal role in the pathology of cancer by maintaining genome integrity, controlling cell proliferation, and regulating tissue homeostasis. Experimental data from genetically modified mice and human premature aging diseases clearly indicate that intact telomere function is crucial for cell proliferation and survival, whereas dysfunctional telomeres can lead to either cancer or aging...

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PMID: 23527617
DOI: 10.1111/febs.12258

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