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Article

Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk.

International journal of cancer - 15 Oct 2015

Brossard Myriam, Fang Shenying, Vaysse Amaury, Wei Qingyi, Chen Wei V, Mohamdi Hamida, Maubec Eve, Lavielle Nolwenn, Galan Pilar, Lathrop Mark, Avril Marie-Françoise, Lee Jeffrey E, Amos Christopher I, Demenais Florence

Abstract excerpt

Genome-wide association studies (GWASs) have characterized 13 loci associated with melanoma, which only account for a small part of melanoma risk. To identify new genes with too small an effect to be detected individually but which collectively influence melanoma risk and/or show interactive effects, we used a two-step analysis strategy including pathway analysis of genome-wide SNP data, in a first step, and...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25892537
DOI: 10.1002/ijc.29570
PMCID: PMC4566921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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