Article

Cell-type-specific meQTL extends melanoma GWAS annotation beyond eQTL and informs melanocyte gene regulatory mechanisms

2021-03-24

Abstract excerpt

While expression quantitative trait loci (eQTL) have been powerful in identifying susceptibility genes from genome-wide association studies (GWAS) findings, most trait-associated loci are not explained by eQTL alone. Alternative QTLs including DNA methylation QTL (meQTL) are emerging, but cell-type-specific meQTL using cells of disease origin has been lacking. Here we established an meQTL dataset using primary mel...

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Literature Corpus work: 697e3d57-1814-5674-8146-d996d1e74fa6
DOI: 10.1101/2021.03.23.436704

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