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Article

A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.

International journal of cancer - 1 Nov 2016

Vaysse Amaury, Fang Shenying, Brossard Myriam, Wei Qingyi, Chen Wei V, Mohamdi Hamida, Vincent-Fetita Lynda, Margaritte-Jeannin Patricia, Lavielle Nolwenn, Maubec Eve, Lathrop Mark, Avril Marie-Françoise, Amos Christopher I, Lee Jeffrey E, Demenais Florence

Abstract excerpt

Breslow thickness (BT) is a major prognostic factor of cutaneous melanoma (CM), the most fatal skin cancer. The genetic component of BT has only been explored by candidate gene studies with inconsistent results. Our objective was to uncover the genetic factors underlying BT using an hypothesis-free genome-wide approach. Our analysis strategy integrated a genome-wide association study (GWAS) of single nucleotide...

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Share to cdc42 GTP-Binding Protein
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gelsolin

Share to Gene Ontology

Share to Melanoma

Share to Melanoma, Cutaneous Malignant

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Source

Open in PubMed Open full text

Identifiers

PMID: 27347659
DOI: 10.1002/ijc.30245
PMCID: PMC5116391

Genes

CDC42
SCIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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