Article
Pleiotropic and sex-specific effects of cancer GWAS SNPs on melanoma risk in the population architecture using genomics and epidemiology (PAGE) study.
PloS one - 1 Jan 2015
Kocarnik Jonathan M, Park S Lani, Han Jiali, Dumitrescu Logan, Cheng Iona, Wilkens Lynne R, Schumacher Fredrick R, Kolonel Laurence, Carlson Chris S, Crawford Dana C, Goodloe Robert J, Dilks Holli H, Baker Paxton, Richardson Danielle, Matise Tara C, Ambite José Luis, Song Fengju, Qureshi Abrar A, Zhang Mingfeng, Duggan David, Hutter Carolyn, Hindorff Lucia, Bush William S, Kooperberg Charles, Le Marchand Loic, Peters Ulrike
Abstract excerpt
BACKGROUND: Several regions of the genome show pleiotropic associations with multiple cancers. We sought to evaluate whether 181 single-nucleotide polymorphisms previously associated with various cancers in genome-wide association studies were also associated with melanoma risk. METHODS: We evaluated 2,131 melanoma cases and 20,353 controls from three studies in the Population Architecture using Genomics and...
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