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Links between melanoma germline risk loci, driver genes and comorbidities: insight from a tissue-specific multi-omic analysis.

Molecular oncology - 1 Apr 2024

Pudjihartono Michael, Golovina Evgeniia, Fadason Tayaza, O'Sullivan Justin M, Schierding William

Abstract excerpt

Genome-wide association studies (GWAS) have associated 76 loci with the risk of developing melanoma. However, understanding the molecular basis of such associations has remained a challenge because most of these loci are in non-coding regions of the genome. Here, we integrated data on epigenomic markers, three-dimensional (3D) genome organization, and expression quantitative trait loci (eQTL) from...

Topics

Humans
Genome-Wide Association Study
Multiomics
Melanoma
Quantitative Trait Loci
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38308491
DOI: 10.1002/1878-0261.13599
PMCID: PMC10994230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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