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Evidence That Aging And Amyloid Promote Microglial Cell Senescence

1 Mar 2007

Abstract excerpt

Advanced age and presence of intracerebral amyloid deposits are known to be major risk factors for development of neurodegeneration in Alzheimer's disease (AD), and both have been associated with microglial activation. However, the specific role of activated microglia in AD pathogenesis remains unresolved. Here we report that microglial cells exhibit significant telomere shortening and reduction of telomerase...

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PMID: 17378753
DOI: 10.1089/rej.2006.9096

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