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Article

Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology

18 Apr 2015

Abstract excerpt

Sirtuins are evolutionarily conserved class III histone deacetylases that have been the focus of intense scrutiny and interest since the discovery of Sir2 as a yeast longevity factor. Early reports demonstrated an important role of Sirt1 in aging and metabolism, but its critical regulatory role in the immune system has only been unveiled in recent years. In this review we discuss the latest advances in...

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PMID: 25890999
DOI: 10.1111/imm.12473

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