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Article

Sirtuin 1 in immune regulation and autoimmunity

22 Nov 2011

Abstract excerpt

The NAD-dependent histone deacetylase sirtuin (Sirt)1 is implicated in a wide variety of physiological processes, ranging from tumorigenesis to mitochondrial biogenesis to neuronal development. Recent studies indicate that Sirt1 is a critical regulator of both the innate and adaptive immune response in mice and its altered functions are likely involved in autoimmune diseases. Small molecules that modulate Sirt1...

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PMID: 22105513
DOI: 10.1038/icb.2011.102

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