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Article

GLI2 inhibition abrogates human leukemia stem cell dormancy

21 Mar 2015

Abstract excerpt

BACKGROUND: Dormant leukemia stem cells (LSC) promote therapeutic resistance and leukemic progression as a result of unbridled activation of stem cell gene expression programs. Thus, we hypothesized that 1) deregulation of the hedgehog (Hh) stem cell self-renewal and cell cycle regulatory pathway would promote dormant human LSC generation and 2) that PF-04449913, a clinical antagonist of the GLI2 transcriptional...

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PMID: 25889765
DOI: 10.1186/s12967-015-0453-9

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