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Article

Tracking molecular relapse of chronic myeloid leukemia by measuring Hedgehog signaling status.

Leukemia & lymphoma - 1 Feb 2013

Cea Michele, Cagnetta Antonia, Cirmena Gabriella, Garuti Anna, Rocco Ilaria, Palermo Claudia, Pierri Ivana, Reverberi Daniele, Nencioni Alessio, Ballestrero Alberto, Gobbi Marco, Carella Angelo Michele, Patrone Franco

Abstract excerpt

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by the expansion of a leukemic stem cell (LSC) clone, carrying a Philadelphia translocation, able to overcome the non-malignant hematopoietic stem cells. The tyrosine kinase inhibitors (TKIs) imatinib, nilotinib...

Read the complete abstract on PubMed

Topics

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Share to Fusion Proteins, bcr-abl
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Patched-1 Receptor

Share to Patched Receptors

Share to Receptors, G-Protein-Coupled

Share to Smoothened Receptor

Source

Identifiers

PMID: 22762548
DOI: 10.3109/10428194.2012.708752

Genes

ABL1
BCR
PTCH1
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22762548-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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