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Article

Targeting leukemic stem cells by breaking their dormancy

9 Jun 2010

Abstract excerpt

Transient or long-term quiescence, the latter referred to as dormancy are fundamental features of at least some adult stem cells. The status of dormancy is likely a critical mechanism for the observed resistance of normal HSCs and leukemic stem cells (LSCs) to anti-proliferative chemotherapy. Recent studies have revealed cytokines such as Interferon-alpha (IFNα) and G-CSF as well as arsenic trioxide (As(2)O(3))...

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PMID: 20599449
DOI: 10.1016/j.molonc.2010.06.001

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