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WNT8B and -9B promote the survival and dissemination of dormant ovarian cancer cells

2026-08-11

Abstract excerpt

Cancer cell dormancy and the resultant resistance to conventional therapies present significant challenges for the successful treatment of high-grade serous ovarian cancer (HGSC). We used genome wide, and specialized sgRNA, libraries in CRISPR-based screens to identify critical cell survival mechanisms in dormancy and metastasis. Our findings demonstrate that low expression Wnt ligands WNT8B and WNT9B are essentia...

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Literature Corpus work
aa1362f5-5b2b-54e0-b48a-f532a9dbcdbd
DOI
10.64898/2026.08.11.744088
Open publication

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WNT8B and -9B promote the survival and dissemination of dormant ovarian cancer cellsDOI 10.64898/2026.08.11.744088
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