Article
Enforcement of stem-cell dormancy by nucleophosmin mutation is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis.
Haematologica - 1 Sept 2025
Merlo Maria Elena Boggio, Mallardo Maria, Luzi Lucilla, De Conti Giulia, Caprioli Chiara, Hillje Roman, Faretta Mario, Restelli Cecilia, Polazzi Andrea, Tabanelli Valentina, Calleri Angelica, Pileri Stefano, Pelicci Pier Giuseppe, Colombo Emanuela
Abstract excerpt
Mutations in the NPM1 gene (NPMc+) and in the FLT3 gene (FLT3-ITD) represent the most frequent co-occurring mutations in acute myeloid leukemia (AML), yet the cellular and molecular mechanisms of their co-operation remain largely unexplored. Using mouse models that faithfully recapitulate human AML, we investigated the impact of these oncogenes on pre-leukemic and leukemic hematopoietic stem cells (HSC), both...
Read the complete abstract on PubMedTopics
- Nucleophosmin
- Animals
- Mice
- Mutation
- Nuclear Proteins