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Article

Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP.

BMC biology - 17 Apr 2015

Aguirre Luis A, Alonso M Eva, Badía-Careaga Claudio, Rollán Isabel, Arias Cristina, Fernández-Miñán Ana, López-Jiménez Elena, Aránega Amelia, Gómez-Skarmeta José Luis, Franco Diego, Manzanares Miguel

Abstract excerpt

BACKGROUND: Recent genome-wide association studies have uncovered genomic loci that underlie an increased risk for atrial fibrillation, the major cardiac arrhythmia in humans. The most significant locus is located in a gene desert at 4q25, approximately 170 kilobases upstream of PITX2, which codes for a transcription factor involved in embryonic left-right asymmetry and cardiac development. However, how this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 4

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Share to Homeobox Protein PITX2

Share to Myocytes, Cardiac

Share to Regulatory Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 25888893
DOI: 10.1186/s12915-015-0138-0
PMCID: PMC4416339

Genes

PITX2
ENPEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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