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Article

Atrial Fibrillation associated chromosome 4q25 variants are not associated with PITX2c expression in human adult left atrial appendages.

PloS one - 1 Jan 2014

Gore-Panter Shamone R, Hsu Jeffery, Hanna Peter, Gillinov A Marc, Pettersson Gosta, Newton David W, Moravec Christine S, Van Wagoner David R, Chung Mina K, Barnard John, Smith Jonathan D

Abstract excerpt

Atrial Fibrillation (AF), the most common sustained arrhythmia, has a strong genetic component, but the mechanism by which common genetic variants lead to increased AF susceptibility is unknown. Genome-wide association studies (GWAS) have identified that the single nucleotide polymorphisms (SNPs) most strongly associated with AF are located on chromosome 4q25 in an intergenic region distal to the PITX2 gene. Our...

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Identifiers

PMID: 24465984
DOI: 10.1371/journal.pone.0086245
PMCID: PMC3899225

Genes

PITX2
ENPEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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