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SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells

13 Mar 2015

Abstract excerpt

BACKGROUND: SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS influences signaling events mediated by heparan sulfate proteoglycans (HSPGs) located on cell surface, which are critical for the interactions with growth factors and their receptors. Alterations in SULF2 expression have been identified in the context of...

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PMID: 25887999
DOI: 10.1186/s13046-015-0141-x

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