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Article

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment

16 Jan 2019

Abstract excerpt

The telomeric protein TRF2 is overexpressed in several human malignancies and contributes to tumorigenesis even though the molecular mechanism is not completely understood. By using a high-throughput approach based on the multiplexed Luminex X-MAP technology, we demonstrated that TRF2 dramatically affects VEGF-A level in the secretome of cancer cells, promoting endothelial cell-differentiation and angiogenesis....

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PMID: 30698737
DOI: 10.1093/nar/gkz041

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