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Article

SULFs in human neoplasia: implication as progression and prognosis factors

21 May 2011

Abstract excerpt

BACKGROUND: The sulfation pattern of heparan sulfate chains influences signaling events mediated by heparan sulfate proteoglycans located on cell surface. SULF1 and SULF2 are two endosulfatases able to cleave specific 6-O sulfate groups within the heparan chains. Their action can modulate signaling processes, many of which with key relevance for cancer development and expansion. SULF1 has been associated with...

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PMID: 21599997
DOI: 10.1186/1479-5876-9-72

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