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Article

Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival.

Genes, chromosomes & cancer - 1 Feb 2011

Yang Ju Dong, Sun Zhifu, Hu Chunling, Lai Jinping, Dove Rebecca, Nakamura Ikuo, Lee Ju-Seog, Thorgeirsson Snorri S, Kang Koo Jeong, Chu In-Sun, Roberts Lewis R

Abstract excerpt

The heparin-degrading endosulfatases sulfatase 1 (SULF1) and sulfatase 2 (SULF2) have opposing effects in hepatocarcinogenesis despite structural similarity. Using mRNA expression arrays, we analyzed the correlations of SULF expression with signaling networks in human hepatocellular carcinomas (HCCs) and the associations of SULF expression with tumor phenotype and patient survival. Data from two mRNA microarray...

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Share to Carcinoma, Hepatocellular
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms

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Source

Open in PubMed Open full text

Identifiers

PMID: 21104785
DOI: 10.1002/gcc.20838
PMCID: PMC3253341

Genes

SULF1
SULF2
IQGAP1
IQGAP2
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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