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Article

Evolution of lysine acetylation in the RNA polymerase II C-terminal domain

9 Mar 2015

Abstract excerpt

BACKGROUND: RPB1, the largest subunit of RNA polymerase II, contains a highly modifiable C-terminal domain (CTD) that consists of variations of a consensus heptad repeat sequence (Y1S2P3T4S5P6S7). The consensus CTD repeat motif and tandem organization represent the ancestral state of eukaryotic RPB1, but across eukaryotes CTDs show considerable diversity in repeat organization and sequence content. These...

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PMID: 25887984
DOI: 10.1186/s12862-015-0327-z

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