Article
Evolutionary diversity and taxon-specific modifications of the RNA polymerase II C-terminal domain.
Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2014
Yang Chunlin, Stiller John W
Abstract excerpt
In model eukaryotes, the C-terminal domain (CTD) of the largest subunit of DNA-dependent RNA polymerase II (RNAP II) is composed of tandemly repeated heptads with the consensus sequence YSPTSPS. The core motif and tandem structure generally are conserved across model taxa, including animals, yeasts and higher plants. Broader investigations revealed that CTDs of many organisms deviate substantially from this...
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