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Article

The poly(C)-binding proteins: A multiplicity of functions and a search for mechanisms

1 Mar 2002

Abstract excerpt

The poly(C) binding proteins (PCBPs) are encoded at five dispersed loci in the mouse and human genomes. These proteins, which can be divided into two groups, hnRNPs K/J and the alphaCPs (alphaCP1-4), are linked by a common evolutionary history, a shared triple KH domain configuration, and by their poly(C) binding specificity. Given these conserved characteristics it is remarkable to find a substantial diversity...

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PMID: 12003487
DOI: 10.1017/s1355838202024627

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