Article
The relationship between methylenetetrahydrofolate reductase polymorphism and hematological malignancy.
Clinical laboratory - 1 Jan 2014
Jiang Ni, Zhu Xishan, Zhang Hongmei, Wang Xiaoli, Zhou Xinna, Gu Jiezhun, Chen Baoan, Ren Jun
Abstract excerpt
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme for folate metabolism. Previous studies suggest a relationship between its single nucleotide polymorphisms (SNP) of C677T and A1298C with a variety of tumor susceptibility including hematological malignancy. SNP frequency d...
Topics
- Adult
- Aged
- Asian People
- Case-Control Studies
- China
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Hematologic Neoplasms
- Humans
- Leukemia, Myeloid
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Polymorphism, Single Nucleotide