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Article

Multicentric occurrence of multiple papillary thyroid carcinomas--HUMARA and BRAF mutation analysis.

Cancer medicine - 1 Aug 2015

Nakazawa Tadao, Kondo Tetsuo, Tahara Ippei, Kasai Kazunari, Inoue Tomohiro, Oishi Naoki, Mochizuki Kunio, Kubota Takeo, Katoh Ryohei

Abstract excerpt

Papillary thyroid carcinomas (PTCs) occasionally form multiple tumor foci in different sites of the same thyroid gland. However, it is controversial whether discrete nodules of PTC arise independently (multicentric occurrence) or are seeded from a single tumor via lymphatic channels (intraglandular metastasis). In order to determine the clonal origin of multiple PTCs, we examined X-chromosome inactivation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins B-raf

Share to Receptors, Androgen

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Source

Open in PubMed Open full text

Identifiers

PMID: 25882744
DOI: 10.1002/cam4.466
PMCID: PMC4559038

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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