Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling.

Molecular cancer - 4 Dec 2008

Aherne Sinéad T, Smyth Paul C, Flavin Richard J, Russell Susan M, Denning Karen M, Li Jing Huan, Guenther Simone M, O'Leary John J, Sheils Orla M

Abstract excerpt

BACKGROUND: Papillary thyroid carcinoma (PTC) frequently presents as multiple tumour-foci within a single thyroid gland or pluriform, with synchronous tumours comprising different histological variants, raising questions regarding its clonality. Among the genetic aberrations described in PTC, the BRAF V600E mutation and ret/PTC activation occur most commonly. Several studies have investigated the genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

Share to MicroRNAs

Share to Mutation

Share to Thyroid Neoplasms

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 19055826
DOI: 10.1186/1476-4598-7-89
PMCID: PMC2612696

Genes

BRAF
MVD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling.PMID 19055826Read ↗

Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma.Semantic proximity Read ↗

Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profilesSemantic proximity Read ↗

Most multifocal papillary thyroid carcinomas acquire genetic and morphotype diversity through subclonal evolution following the intra-glandular spread of the initial neoplastic clone.Semantic proximity Read ↗

Heterogeneity of Thyroid Cancer.Semantic proximity Read ↗

Multifocal Papillary Thyroid Carcinomas With Discordant Molecular Drivers: Emphasizing the Morphology and Collision Tumors.Semantic proximity Read ↗

Molecular characterisation and clinical correlation of papillary thyroid microcarcinoma.Semantic proximity Read ↗

Single thyroid tumour showing multiple differentiated morphological patterns and intramorphological molecular genetic heterogeneity.Semantic proximity Read ↗

Risk factors associated with aggressive tumor phenotypes in papillary thyroid microcarcinoma: a systematic review and meta-analysis.Semantic proximity Read ↗

Relevance of BRAF and NRAS mutations in the primary tumor and metastases of papillary thyroid carcinomas.Semantic proximity Read ↗

Molecular and histopathologic characteristics of multifocal papillary thyroid carcinoma.Semantic proximity Read ↗

Clinical and molecular features of progressive papillary thyroid microcarcinoma.Semantic proximity Read ↗

Intratumoral Genetic Heterogeneity in Papillary Thyroid Cancer: Occurrence and Clinical SignificanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.