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Article

Molecular Evidence for the Same Clonal Origin of Multifocal Papillary Thyroid Carcinomas

15 Apr 2006

Abstract excerpt

PURPOSE: Patients with papillary thyroid carcinoma often have two or more distinct papillary tumors at thyroidectomy. Whether these multifocal papillary lesions are clonally related or whether they arise independently is unknown as previous studies have shown conflicting results. Molecular analysis of microsatellite alterations and X-chromosome inactivation status in separate tumors from the same patient can be...

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PMID: 16638846
DOI: 10.1158/1078-0432.ccr-05-2818

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