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Article

Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma.

Pathology - 1 Jan 2010

Jovanovic Lidija, Delahunt Brett, McIver Bryan, Eberhardt Norman L, Bhattacharya Alokananda, Lea Rod, Grebe Stefan K G

Abstract excerpt

AIMS: This study was undertaken to investigate the genetic factors underlying the development of multifocality and phenotypic diversity in multifocal papillary thyroid carcinoma (mPTC). METHODS: Loss of heterozygosity (LOH) and BRAF(V600E) mutation status were analysed in a total of 55 individual tumour foci from 18 cases of mPTC. The genetic findings and morphology of tumour foci were then compared. RESULTS:...

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Source

Identifiers

PMID: 20854070
DOI: 10.3109/00313025.2010.508780

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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