Article
Copy number alteration and uniparental disomy analysis categorizes Japanese papillary thyroid carcinomas into distinct groups.
PloS one - 1 Jan 2012
Matsuse Michiko, Sasaki Kensaku, Nishihara Eijun, Minami Shigeki, Hayashida Chisa, Kondo Hisayoshi, Suzuki Keiji, Saenko Vladimir, Yoshiura Koh-ichiro, Mitsutake Norisato, Yamashita Shunichi
Abstract excerpt
The aim of the present study was to investigate chromosomal aberrations in sporadic Japanese papillary thyroid carcinomas (PTCs), concomitant with the analysis of oncogene mutational status. Twenty-five PTCs (11 with BRAF(V600E), 4 with RET/PTC1, and 10 without mutation in HRAS, KRAS, NRAS, BRAF, RET/PTC1, or RET/PTC3) were analyzed using Genome-Wide Human SNP Array 6.0 which allows us to detect copy number...
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