Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The heterogeneous distribution of BRAF mutation supports the independent clonal origin of distinct tumor foci in multifocal papillary thyroid carcinoma.

The Journal of clinical endocrinology and metabolism - 1 Sept 2007

Giannini Riccardo, Ugolini Clara, Lupi Cristiana, Proietti Agnese, Elisei Rossella, Salvatore Giuliana, Berti Piero, Materazzi Gabriele, Miccoli Paolo, Santoro Massimo, Basolo Fulvio

Abstract excerpt

CONTEXT: Papillary thyroid carcinoma (PTC) is frequently multifocal. Independent PTC foci may occur either from intraglandular metastases from a single dominant tumor or as unrelated neoplastic clones. In rare cases, the simultaneous presence of PTC foci of different histopathological subtypes points to independent sites of tumor formation. OBJECTIVES: We examined the pattern of BRAF mutations in noncontiguous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Papillary
Share to Clone Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Lymph Nodes

Share to Lymphatic Metastasis

Share to Neoplasms, Multiple Primary

Share to Neoplastic Stem Cells

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 17535994
DOI: 10.1210/jc.2007-0594

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The heterogeneous distribution of BRAF mutation supports the independent clonal origin of distinct tumor foci in multifocal papillary thyroid carcinoma.PMID 17535994Read ↗

Analysis of differential BRAF(V600E) mutational status in multifocal papillary thyroid carcinoma: evidence of independent clonal origin in distinct tumor foci.Semantic proximity Read ↗

Molecular and histopathologic characteristics of multifocal papillary thyroid carcinoma.Semantic proximity Read ↗

Relevance of BRAF and NRAS mutations in the primary tumor and metastases of papillary thyroid carcinomas.Semantic proximity Read ↗

Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma.Semantic proximity Read ↗

Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profilesSemantic proximity Read ↗

Most multifocal papillary thyroid carcinomas acquire genetic and morphotype diversity through subclonal evolution following the intra-glandular spread of the initial neoplastic clone.Semantic proximity Read ↗

Multifocal Papillary Thyroid Carcinomas With Discordant Molecular Drivers: Emphasizing the Morphology and Collision Tumors.Semantic proximity Read ↗

Molecular Evidence for the Same Clonal Origin of Multifocal Papillary Thyroid CarcinomasSemantic proximity Read ↗

Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling.Semantic proximity Read ↗

Molecular analysis of multifocal papillary thyroid carcinomaSemantic proximity Read ↗

Different structural components of conventional papillary thyroid carcinoma display mostly identical BRAF status.Semantic proximity Read ↗

Progression of solitary and multifocal papillary thyroid carcinoma - a retrospective study of 368 patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.