Article
Cyclin B3 and dynein heavy chain cooperate to increase fitness in the absence of mdf-1/MAD1 in Caenorhabditis elegans.
Cell cycle (Georgetown, Tex.) - 1 Jan 2014
Tarailo-Graovac Maja, Wong Tammy, Qin Zhaozhao, Flibotte Stephane, Taylor Jon, Moerman Donald G, Rose Ann M, Chen Nansheng
Abstract excerpt
Spindle assembly checkpoint (SAC) ensures genome stability by delaying anaphase onset until all the chromosomes have achieved proper spindle attachment. Once correct attachment has been achieved, SAC must be silenced. In the absence of mdf-1/MAD1, an essential SAC component, Caenorhabditis elegans cannot propagate beyond 3 generations. Previously, in a dog-1(gk10)/FANCJ mutator background, we isolated a...
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