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Article

Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo.

International journal of cancer - 15 Mar 2010

Zittermann Sandra I, Capurro Mariana I, Shi Wen, Filmus Jorge

Abstract excerpt

The heterogeneity of the molecular pathology of HCC poses a formidable obstacle to the development of non-cytotoxic therapies. Several pro-tumorigenic signaling pathways can be aberrantly activated in HCC, including those triggered by Wnts. Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan that is overexpressed in most HCCs, promotes the growth of these tumors by stimulating Wnt signaling. Because...

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Share to Glycosylphosphatidylinositols
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Share to Liver Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19816934
DOI: 10.1002/ijc.24941

Genes

GPC3
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo.PMID 19816934Read ↗

Silencing of the glypican-3 gene affects the biological behavior of human hepatocellular carcinoma cellsSemantic proximity Read ↗

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Structural and Functional Impact of Posttranslational Modification of Glypican-3 on Liver CarcinogenesisSemantic proximity Read ↗

New tumor suppressor microRNAs target glypican-3 in human liver cancerSemantic proximity Read ↗

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Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathwaySemantic proximity Read ↗

Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinomaSemantic proximity Read ↗

Engineered E. coli OMVs Carrying the Membrane-Binding hGC33 Fragment Precisely Target Liver Cancer and Effectively Treat TumorSemantic proximity Read ↗

Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancerSemantic proximity Read ↗

Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway.Semantic proximity Read ↗

Ablation of glypican-3 enhances radiosensitivity in liver cancer by prolonging G2/M arrest and activating the ATM/CHK2 pathwaySemantic proximity Read ↗

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