Article
Plakophilin3 loss leads to an increase in lipocalin2 expression, which is required for tumour formation.
Experimental cell research - 15 Aug 2018
Basu Srikanta, Chaudhary Nazia, Shah Sanket, Braggs Carol, Sawant Aakanksha, Vaz Simone, Thorat Rahul, Gupta Sanjay, Dalal Sorab N
Abstract excerpt
An increase in tumour formation and metastasis are observed upon plakophilin3 (PKP3) loss. To identify pathways downstream of PKP3 loss that are required for increased tumour formation, a gene expression analysis was performed, which demonstrated that the expression of lipocalin2 (LCN2) was elevated upon PKP3 loss and this is consistent with expression data from human tumour samples suggesting that PKP3 loss...
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