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Article

Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway.

Cancer gene therapy - 1 Aug 2021

Fang Long, Gao Chun, Bai Ru-Xue, Wang Hui-Fen, Du Shi-Yu

Abstract excerpt

Hepatocellular carcinoma (HCC) is recognized as the most common malignancy of the liver in adults. Many human cancers have been associated with the oncogenic activation of the Wnt/β-catenin signaling pathway. The secreted frizzled-related proteins (sFRPs) function as negative regulators of the Wnt signaling and have important implications in carcinogenesis. This study aims to investigate the possible regulatory...

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PMID: 32978504
DOI: 10.1038/s41417-020-0201-z

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