Article
Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk.
European journal of human genetics : EJHG - 1 Jan 2016
Baert-Desurmont Stéphanie, Charbonnier Françoise, Houivet Estelle, Ippolito Lorena, Mauillon Jacques, Bougeard Marion, Abadie Caroline, Malka David, Duffour Jacqueline, Desseigne Françoise, Colas Chrystelle, Pujol Pascal, Lejeune Sophie, Dugast Catherine, Buecher Bruno, Faivre Laurence, Leroux Dominique, Gesta Paul, Coupier Isabelle, Guimbaud Rosine, Berthet Pascaline, Manouvrier Sylvie, Cauchin Estelle, Prieur Fabienne, Laurent-Puig Pierre, Lebrun Marine, Jonveaux Philippe, Chiesa Jean, Caron Olivier, Morin-Meschin Marie-Emmanuelle, Polycarpe-Osaer Florence, Giraud Sophie, Zaanan Aziz, Bonnet Delphine, Mansuy Ludovic, Bonadona Valérie, El Chehadeh Salima, Duhoux François, Gauthier-Villars Marion, Saurin Jean-Christophe, Collonge-Rame Marie-Agnès, Brugières Laurence, Wang Qing, Bressac-de Paillerets Brigitte, Rey Jean-Marc, Toulas Christine, Buisine Marie-Pierre, Bronner Myriam, Sokolowska Joanna, Hardouin Agnès, Cailleux Anne-Françoise, Sebaoui Hakim, Blot Julien, Tinat Julie, Benichou Jacques, Frebourg Thierry
Abstract excerpt
To determine if the at-risk single-nucleotide polymorphism (SNP) alleles for colorectal cancer (CRC) could contribute to clinical situations suggestive of an increased genetic risk for CRC, we performed a prospective national case-control study based on highly selected patients (CRC in two first-degree relatives, one before 61 years of age; or CRC diagnosed before 51 years of age; or multiple primary CRCs, the...
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