Article
Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.
Gastroenterology - 1 Jan 2009
Wijnen Juul T, Brohet Richard M, van Eijk Ronald, Jagmohan-Changur Shanty, Middeldorp Anneke, Tops Carli M, van Puijenbroek Mario, Ausems Margreet G E M, Gómez García Encarna, Hes Frederik J, Hoogerbrugge Nicoline, Menko Fred H, van Os Theo A M, Sijmons Rolf H, Verhoef Senno, Wagner Anja, Nagengast Fokko M, Kleibeuker Jan H, Devilee Peter, Morreau Hans, Goldgar David, Tomlinson Ian P, Houlston Richard S, van Wezel Tom, Vasen Hans F A
Abstract excerpt
BACKGROUND & AIMS: Recent genome-wide association studies have identified common low-risk variants for colorectal cancer (CRC). To assess whether these influence CRC risk in the Lynch syndrome, we genotyped these variants in a large series of proven mutation carriers. METHODS: We studied 675 individuals from 127 different families from the Dutch Lynch syndrome Registry whose mutation carrier status was known. We...
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