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Article

DEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain.

Translational psychiatry - 14 Apr 2015

Ohi K, Ursini G, Li M, Shin J H, Ye T, Chen Q, Tao R, Kleinman J E, Hyde T M, Hashimoto R, Weinberger D R

Abstract excerpt

A genome-wide association study of cognitive deficits in patients with schizophrenia in Japan found association with a missense genetic variant (rs7157599, Asn8Ser) in the delta(4)-desaturase, sphingolipid 2 (DEGS2) gene. A replication analysis using Caucasian samples showed a directionally consistent trend for cognitive association of a proxy single-nucleotide polymorphism (SNP), rs3783332. Although the DEGS2...

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Source

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Identifiers

PMID: 25871975
DOI: 10.1038/tp.2015.45
PMCID: PMC4462608

Genes

DEGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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