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Article

What genes are differentially expressed in individuals with schizophrenia? A systematic review.

Molecular psychiatry - 1 Mar 2022

Merikangas Alison K, Shelly Matthew, Knighton Alexys, Kotler Nicholas, Tanenbaum Nicole, Almasy Laura

Abstract excerpt

Schizophrenia is a severe, complex mental disorder characterized by a combination of positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is highly heritable (~80%) with multifactorial etiology and complex polygenic genetic architecture. Despite the large number of genetic variants associated with schizophrenia, few causal variants have been established. Gaining insight into the...

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Identifiers

PMID: 35091668
DOI: 10.1038/s41380-021-01420-7
PMCID: PMC9095490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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