Association of Transforming Growth Factor Beta-1 (TGF-β1) Genetic Variation with Type 2 Diabetes and End Stage Renal Disease in Two Large Population Samples from North India.

doi:10.1089/omi.2015.0005

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Article

Association of Transforming Growth Factor Beta-1 (TGF-β1) Genetic Variation with Type 2 Diabetes and End Stage Renal Disease in Two Large Population Samples from North India.

Omics : a journal of integrative biology - 1 May 2015

Raina Priyanka, Sikka Ruhi, Kaur Ramandeep, Sokhi Jasmine, Matharoo Kawaljit, Singh Virinder, Bhanwer A J S

Abstract excerpt

Geographic and ethnic differences impart an immense influence on the genetic susceptibility to Type 2 diabetes (T2D) and diabetic nephropathy (DN). Transforming growth factor-beta1 (TGF-β1), a ubiquitously expressed pro-fibrotic cytokine plays a pivotal role in mediating the hypertrophic and fibrotic manifestations of DN. The present study is aimed to study the association of TGF-β1 g.869T>C (rs1800470) and...

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PMID: 25871499
DOI: 10.1089/omi.2015.0005
PMCID: PMC4424967

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