Article
Transforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiency.
Nephron. Experimental nephrology - 1 Jan 2005
Khalil M Salah, El Nahas A M, Blakemore A I F
Abstract excerpt
Associations have been described between polymorphisms of cytokine and growth factor genes and susceptibility to, or progression of, an increasing number of diseases. TGF-beta1 plays an important role in the pathogenesis of experimental and clinical glomerulosclerosis and tubulointerstitial fibrosis. In this study, single nucleotide polymorphisms (SNPs) in the TGFbeta1 gene were investigated as possible markers...
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