Genetic and inflammatory interplay between IL1B (-511C/T) polymorphism and diabetic nephropathy in type 2 diabetes.

doi:10.1016/j.cyto.2026.157164

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Article

Genetic and inflammatory interplay between IL1B (-511C/T) polymorphism and diabetic nephropathy in type 2 diabetes.

Cytokine - 1 Jul 2026

Zaki Maysaa El Sayed, Salem Eman Hosney Mohammed, Elbaz Amro Abdel-Hamid, Essa Sara Ghaleb

Abstract excerpt

BACKGROUND: Inflammatory cytokines, particularly interleukin-1β (IL-1β), have a main role in diabetic nephropathy (DN) pathogenesis. Genetic variations within the IL1B promoter region may modulate cytokine expression and affect vulnerability to renal injury in type 2 diabetes mellitus (T2DM). We aimed to assess the correlation between the IL1B (-511C/T;rs16944) polymorphism, IL-1β serum levels, and renal function...

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Identifiers

PMID: 42102746
DOI: 10.1016/j.cyto.2026.157164

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IL1B

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